Premature Ovarian Failure and Infertility

Maternal age, physical abnormalities, hormonal imbalances and ovulatory dysfunction can all impact the ability to get pregnant. Premature ovarian failure is one type of ovulatory disruption that can make getting pregnant a challenge.
Approximately 1 in 100 women have premature ovarian failure.

What Is Premature Ovarian Failure?

When girls reach puberty and begin menstruation, their bodies usually release an egg during ovulation each cycle, approximately every 28 to 32 days. For most women, menstrual cycles begin in their early teens and continue until the onset of menopause, usually in their late 40s and early 50s. With premature ovarian failure, your ovaries stop working before age 40, producing few to no eggs after this point.

Causes of Premature Ovarian Failure

Sometimes, the exact cause of this condition may not be easily identifiable. Congenital abnormalities, hormone deficiencies, autoimmune disorders and damage from chemotherapy can contribute to premature ovarian failure.

Diagnosing Premature Ovarian Failure

Symptoms, such as hot flashes, irregular or absent cycles, irritability, vaginal dryness and decreased sex drive. To confirm premature ovarian failure, following tests are done:
Follicle-stimulating hormone (FSH) test: Unusually high levels of FSH in the blood could indicate premature ovarian failure. Luteinizing hormone (LH) test: With premature ovarian failure, the level of LH is usually lower than the level of FSH. Serum estradiol test: In women with premature ovarian failure, the blood level of estradiol, a type of estrogen, is often low.

Treatment Options for Premature Ovarian Failure

With this condition, achieving pregnancy from your own eggs is usually difficult. in-vitro fertilization (IVF) OR ICSI with donor eggs is the treatment of choice.